Therapeutic Indication
Treats neuropathic pain associated with fibromyalgia, diabetic neuropathy, spinal cord injury.
About Composition
Pregabalin has similar structure to the inhibitory neurotransmitter i.e. Gaba (Gama amino butyric acid) and is commonly used in the treatment of neuropathic pain.
Nortriptyline belongs to the category of tricyclic antidepressants drugs. It helps to mainly treats depression but it is also used to treat chronic pain, irritatable bowel syndrome.
Mechanism of Action
Pregabalin binds to the alpha-2 subunits of the voltage gated calcium channels present in central nervous system.
Nortriptyline prevents the reuptake process at the neuronal synapse junction of serotonin and nor-adrenergic receptors.
Pharmacokinetics
Pregabalin:
It is absorbed orally
It does not show any protein binding
It is 2% metabolized in the liver
It is excreted unchanged in the urine
Nortriptyline:
It is absorbed orally
It is 93% bound to plasma proteins
It undergoes demethylation and hydroxylation
It is excreted via urine
Side Effects
● Constipation
● Difficulty in urination
● Weight gain
● Sleepiness
● Blurred vision
● Dryness of mouth
Contraindication
● Contraindicated in depression
● Contraindicated in lung disorders
Precaution
Do not use grapefruit with this combination
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